MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction
| Autor: | José Morales-Roselló, Gabriela Loscalzo, Eva María García-Lopez, José Santiago Ibañez Cabellos, José Luis García-Gimenez, Antonio José Cañada Martínez, Alfredo Perales Marín |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 17, Iss 11, Pp 1345-1356 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2021.2023271 |
| Popis: | To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P |
| Databáze: | Directory of Open Access Journals |
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