Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

Autor: Pedro Manzke, Talyta Grippe, Georgia L. Tavares, Lucas C. Leal, Emmanuel Roze, Emmanuelle Apartis, Ronaldo M. Dias, André G. Ferreira
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Tremor and Other Hyperkinetic Movements, Pp 1-3 (2018)
Druh dokumentu: article
ISSN: 2160-8288
DOI: 10.7916/D8NK4XVP
Popis: Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.
Databáze: Directory of Open Access Journals