Investigation of the Neuropathic Pain Caused by Syringomyelia Associated with Chiari I Malformation

Autor: Toshitaka Seki, Shuji Hamauchi, Masayoshi Yamazaki, Kazutoshi Hida, Shunsuke Yano, Kiyohiro Houkin
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Asian Spine Journal, Vol 13, Iss 4, Pp 648-653 (2019)
Druh dokumentu: article
ISSN: 1976-1902
1976-7846
24273457
DOI: 10.31616/asj.2018.0242
Popis: Study Design Retrospective cohort study. Purpose To investigate the correlation between the syrinx morphology and neuropathic pain caused by syringomyelia associated with Chiari I malformation. Overview of Literature Neuropathic pain caused by syringomyelia is refractory and markedly impairs the patient. Methods We examined 24 patients with neuropathic pain caused by syringomyelia associated with Chiari I malformation. We statistically analyzed the illness duration and age at surgery between patients with and without neuropathic pain. Additionally, we classified the morphology of the syringes into deviated (D), enlarged (E), central (C), and bulkhead (B) types using T2-weighted axial imaging. Moreover, we investigated the correlation between syrinx morphology and neuropathic pain. A Mann–Whitney U-test was performed to compare between the presence or absence of neuropathic pain and the presence or absence of type D syringes. Results The median age at surgery was 27.5 years, and the median illness duration was 24 months. Among the 24 patients, 11 had preoperative neuropathic pain, one of which was free of neuropathic pain during the final follow-up period. Among patients with neuropathic pain, the syringes’ preoperative morphology was type D in nine patients and types E and C in one patient each. No patient exhibited type B morphology. Among patients without neuropathic pain, the preoperative morphology of the syringes was type D in three patients, type E in seven patients, and types C and B in two patients each. For types D and E, a correlation between neuropathic pain and syrinx morphology was observed. Moreover, type D was associated with significant neuropathic pain in both preoperative and postoperative states. Conclusions This study showed a correlation between the morphological features of the syringes and the occurrence of neuropathic pain in patients with syringomyelia associated with Chiari I malformation.
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