Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
| Autor: | Achilea Lisboa Bittencourt, Luiz Antonio Rodrigues de Freitas, Margarida L. Pompeu, Maria Lucia Vieira, Aldina Barral |
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| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 85, Iss 1, Pp 53-59 (1990) |
| Druh dokumentu: | article |
| ISSN: | 0074-0276 1678-8060 |
| DOI: | 10.1590/S0074-02761990000100008 |
| Popis: | The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection. |
| Databáze: | Directory of Open Access Journals |
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