A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
| Autor: | Torben Knuschke, Sebastian Kollenda, Christina Wenzek, Gennadiy Zelinskyy, Philine Steinbach, Ulf Dittmer, Jan Buer, Matthias Epple, Astrid M. Westendorf |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | mBio, Vol 12, Iss 1 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2161-2129 2150-7511 |
| DOI: | 10.1128/mBio.02121-20 |
| Popis: | Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown impressive results against solid tumors. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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