Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders

Autor:	Rita Moretti, Mauro Giuffrè, Nicola Merli, Paola Caruso, Stefano Di Bella, Claudio Tiribelli, Lory Saveria Crocè
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	HCV hepatitis C stroke nervous system cryoglobulinemia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Brain Sciences, Vol 11, Iss 12, p 1569 (2021)
Druh dokumentu:	article
ISSN:	2076-3425
DOI:	10.3390/brainsci11121569
Popis:	Hepatitis C Virus (HCV), despite being a hepatotropic virus, is the causative agent of many systemic disorders, such as vasculitis, autoimmune diseases, lymphoproliferative disorders, and a broad spectrum of neurological and psychiatric manifestations. Although symptoms have been misdiagnosed or underdiagnosed, only recently, evidence of direct (inflammatory) or indirect (immune-mediated) HCV-dependent cerebral effects has been established. HCV infection can promote acute inflammatory response, pro-coagulative status and ischemic disorders, and neurodegeneration. These effects rely on cerebral HCV replication, possibly mediated by blood–brain barrier alterations. Further study is needed to better understand the HCV-related mechanisms of brain damage.
Databáze:	Directory of Open Access Journals
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