Interplay between systemic inflammation, anemia, and mycobacterial dissemination and its impact on mortality in TB-associated HIV: a prospective cohort study

Autor: Mariana Araújo-Pereira, Charlotte Schutz, Beatriz Barreto-Duarte, David Barr, Klauss Villalva-Serra, Caian L. Vinhaes, Amy Ward, Graeme Meintjes, Bruno B. Andrade
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Immunology, Vol 14 (2023)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2023.1177432
Popis: IntroductionAnemia frequently affects people living with HIV (PLHIV). Nevertheless, the impact of anemia on treatment outcomes of patients with HIV-associated tuberculosis (TB) and the underlying molecular profiles are not fully characterized. The aim of this study was to investigate the interplay between anemia, the systemic inflammatory profile, dissemination of TB and death in HIV-TB patients in an ad hoc analysis of results from a prospective cohort study.Methods496 hospitalized PLHIV ≥18 years old, with CD4 count
Databáze: Directory of Open Access Journals