Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner
| Autor: | Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H. |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Endocrine Regulations, Vol 57, Iss 1, Pp 252-261 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1336-0329 2023-0028 |
| DOI: | 10.2478/enr-2023-0028 |
| Popis: | Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma. Previous studies have shown that the knockdown of ERN1 (endoplasmic reticulum to nucleus signaling) significantly suppressed the glioblastoma cell proliferation and modified the hypoxia regulation. The present study is aimed to investigate the impact of hypoxia on the expression of PHGDH (phosphoglycerate dehydrogenase), PSAT1 (phosphoserine aminotransferase 1), PSPH (phosphoserine phosphatase), ATF4 (activating transcription factor 4), and SHMT1 (serine hydroxymethyltransferase 1) in U87MG glioblastoma cells in relation to knockdown of ERN1 with the intent to reveal the role of ERN1 signaling pathway on the endoplasmic reticulum stress-dependent regulation of expression of these genes. |
| Databáze: | Directory of Open Access Journals |
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