An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

Autor: Mati Mann, Arnav Mehta, Jimmy L. Zhao, Kevin Lee, Georgi K. Marinov, Yvette Garcia-Flores, Li-Fan Lu, Alexander Y. Rudensky, David Baltimore
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00972-z
Popis: MicroRNAs (miR) are important regulators of gene transcription, with miR-155 and miR-146a both implicated in macrophage activation. Here the authors show that NF-κB signalling, miR-155 and miR-146a form a complex network of cross-regulations to control gene transcription in macrophages for modulating inflammatory responses.
Databáze: Directory of Open Access Journals