| Autor: |
Renata Spener-Gomes, Allyson Guimarães Costa, Hilda Ferreira de Melo, Alexandra Brito de Souza, Francisco Beraldi-Magalhães, Jaquelane Silva Jesus, María B. Arriaga, Afrânio Kritski, Izabella Safe, Bruno B. Andrade, Anete Trajman, Marcelo Cordeiro-Santos |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 105, Iss , Pp 743-745 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2021.03.022 |
| Popis: |
Objectives: Bacteriological confirmation of extrapulmonary tuberculosis (EPTB) is challenging for several reasons: the paucibacillary nature of the sample; scarce resources, mainly in middle and low-income countries; the need for hospitalization; and unfavorable outcomes. We evaluated the diagnostic role of respiratory specimen examination prospectively in a cohort of patients with presumptive EPTB. Methods: From July 2018 to January 2019, in a tuberculosis (TB)/HIV reference hospital, a cohort of 157 patients with presumed EPTB was evaluated. Xpert® MTB/RIF Ultra or a culture-positive result was considered for bacteriologically confirmed TB. Results: Out of 157 patients with presumptive EPTB, 97 (62%) provided extrapulmonary and respiratory specimens and 60 (38%) extrapulmonary specimens only. Of the 60 patients with extrapulmonary samples, 5 (8%) were positive. Of those with respiratory and extrapulmonary samples, 27 (28%) were positive: 10 in both the respiratory and extrapulmonary samples, 6 in the extrapulmonary sample only, and 11 in the respiratory sample only. A respiratory specimen examination increased by 6-fold the chance of bacteriological confirmation of TB (odds ratio = 5.97 [1.11–47.17]). Conclusion: We conclude that respiratory samples should be examined in patients with presumptive EPTB. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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