| Autor: |
Dionne C.W. Braeken, Roisin Bavalia, Yvonne M.C. Henskens, Hugo ten Cate, Rutger C.C. Hengeveld, Barbara A. Hutten, Saskia Middeldorp, Michiel Coppens, An K. Stroobants |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Thrombosis Update, Vol 11, Iss , Pp 100139- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5727 |
| DOI: |
10.1016/j.tru.2023.100139 |
| Popis: |
Background: Routine monitoring direct oral anticoagulants (DOAC) is not recommended, yet DOAC levels are frequently measured in clinical practice. Interpretation of levels, especially those outside expected ranges, is challenging. Until now it's unclear which patients are at risk for these levels. Aim: Identify clinical characteristics of patients with DOAC levels outside expected ranges. Methods: Patients of 2 Dutch academic medical centers with a DOAC concentration measured between 2012 and 2019 were included. DOAC levels above upper limit peak and below lower limit trough ranges, based on DOAC registration trials, were assigned outside expected range. Differences between patients were evaluated using Chi-square, independent sample-T tests and multivariable logistic regression analysis. Results: Of 597 patients with DOAC measurement, 108 (18.1%) had levels outside expected ranges. Compared to patients with levels within range, patients with levels above range (n = 64) were older (71.1 vs. 60.6 years), more often had creatinine clearance |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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