The Effects of Aerobic Training and Garlic Supplementation on Superoxide Dismutase, Glutathione Peroxidase and Malondialdehyde of Brain Tissue in Aged Rats with Parkinson’s Disease
| Autor: | Morteza Hosseinzadeh, Asieh Abbasi Daloii, Seyed Ali Hoseini, Ahmad Abdi |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 227, Pp 25-35 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Disorder in the brain oxidant-antioxidant system is the main cause of neurodegenerative diseases. Although the favorable effects of exercise and garlic supplementation on nervous system disorders are known, but their interactive effect is not well known. Therefore, the aim of the present study was to determine the effects of aerobic training and garlic supplementation on superoxide dismutase, glutathione peroxidase and malondialdehyde of brain tissue in aged rats with Parkinson’s disease. Materials and methods: 40 Sprague-Dawley male rats (weight 250±20 gr) were randomly divided into five groups (1) healthy control, (2) Parkinson's control, (2) Parkinson's- aerobic exercise, (3) Parkinson's- garlic supplement and (5) Parkinson's-aerobic exercise-garlic supplement. In this study, rats were infected with Parkinson's disease by injecting 2 mg/kg of reserpine. Aerobic training was performed five sessions a week and each session lasted 15-48 minutes at speed of 10-24 meters per minute, for eight weeks. Supplement groups received daily 500 mg/kg garlic by gavage. Data were analyzed by one-way analysis of variance and Tukey post hoc test at the P |
| Databáze: | Directory of Open Access Journals |
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