Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Autor: Bas Molenaar, Louk T. Timmer, Marjolein Droog, Ilaria Perini, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Hesther de Ruiter, Monika M. Gladka, Eva van Rooij
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01636-3
Popis: Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repair
Databáze: Directory of Open Access Journals
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