Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis
| Autor: | Shadi Saghafi, Sakineh Amoueian, Mehdi Montazer, Roshanak Bostan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Iranian Journal of Basic Medical Sciences, Vol 14, Iss 49 (2011) |
| Druh dokumentu: | article |
| ISSN: | 2008-3866 2008-3874 46519025 |
| Popis: | AbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. ResultsThe male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs. 13.6±0.08). There was no statistically significant difference between PG and IG.ConclusionThe current study supports the common nature of pyogenic granulomas and inflammatory gingivitis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|