Sensitivity analysis unveils the interplay of drug-sensitive and drug-resistant Glioma cells: Implications of chemotherapy and anti-angiogenic therapy

Autor:	Latifah Hanum, Dwi Ertiningsih, Nanang Susyanto
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	drug-resistance angiogenic dormancy anti-angiogenic therapy sensitivity analysis Mathematics QA1-939 Applied mathematics. Quantitative methods T57-57.97
Zdroj:	Electronic Research Archive, Vol 32, Iss 1, Pp 72-89 (2024)
Druh dokumentu:	article
ISSN:	2688-1594
DOI:	10.3934/era.2024004?viewType=HTML
Popis:	This study presented a glioma growth model that accounts for drug-sensitive and drug-resistant cells in response to chemotherapy and anti-angiogenic therapy. Chemotherapy induces mutations in drug-sensitive cells, leading to the emergence of drug-resistant cells and highlighting the benefits of combined therapy. Anti-angiogenic therapy can mitigate mutations by inducing angiogenic dormancy. We have identified two reproduction numbers associated with the non-cell and disease-free states. Numerical sensitivity analysis has highlighted influential parameters that control glioma growth dynamics, emphasizing the interactions between drug-sensitive and drug-resistant cells. To reduce glioma endemicity among sensitive cases, it was recommended to decrease chemotherapy expenditure, increase angiogenic dormancy, and adjust chemotherapy infusion rates. In addition, to combat resistance to glioma endemicity, enhancing angiogenic dormancy is crucial.
Databáze:	Directory of Open Access Journals
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