Ibuprofen: Original Versus Green Synthesis
| Autor: | Alina Crina MUREŞAN |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, Vol 41, Iss 3 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2668-4748 2668-4756 |
| DOI: | 10.35219/mms.2018.3.05 |
| Popis: | This paper makes a parallel between the original route versus the green route of Ibuprofen (non-steroidal anti-inflammatory drugs most commonly recommended) synthesis. The original route contained six steps with stoichiometric reagents (some reagents are very toxic: hydrochloric acid, ammonia), a lot of intermediate products, relatively low atom efficiency equal to 40.04% and substantial inorganic salt formation (aluminium trichloride hydrate). The green route of Ibuprofen synthesis developed only three steps, a lower amount of waste and by-products (only acetic acid that can be used for another applications) and an atom efficiency of 77.44%. The green route for Ibuprofen synthesis is an exquisite example of a simple and elegant chemical/pharmaceutical manufacturing process and the nearly complete atom utilization of this streamlined process truly makes it a wasteminimizing, environmentally friendly technology. |
| Databáze: | Directory of Open Access Journals |
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