| Autor: |
Jianfeng Li, Silvia Garavaglia, Zhaofeng Ye, Andrea Moretti, Olga V. Belyaeva, Alison Beiser, Md Ibrahim, Anna Wilk, Steve McClellan, Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili, E. Alan Salter, Andrzej Wierzbicki, Marie E. Migaud, Steven J. Mullett, Nathan A. Yates, Carlos J. Camacho, Menico Rizzi, Robert W. Sobol |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3642 |
| DOI: |
10.1038/s42003-021-02949-7 |
| Popis: |
Using in silico modeling, Li et al. identify a selective inhibitor for aldehyde dehydrogenase isoform ALDH1A3, which is highly expressed in mesenchymal glioma stem cells and therefore a potential drug target. They solve the structure of the ALDH1A3/MCI-INI-3 inhibitor complex and find that the inhibitor is as efficient as ALDH1A3 depletion in preventing retinoic acid biosynthesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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