| Autor: |
Malini Suresh Nair, Nigel C. Dao, Daniela Lopez Melean, Keith R. Griffith, W. David Starnes, J. Brody Moyer, Avery R. Sicher, Dakota F. Brockway, Kathleen D. Meeks, Nicole A. Crowley |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Brain Research Bulletin, Vol 186, Iss , Pp 38-46 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1873-2747 |
| DOI: |
10.1016/j.brainresbull.2022.05.010 |
| Popis: |
Alcohol use disorder (AUD) is characterized by alcohol use coupled with chronic relapse and involves brain regions including the bed nucleus of the stria terminalis (BNST). Here, we explore whether a subpopulation of BNST neurons, somatostatin (SST) expressing GABAergic neurons, play a role in an animal model of binge-like alcohol consumption, the Drinking in the Dark (DID) model. Chemogenetic activation of BNST SST neurons reduced binge alcohol consumption in female but not male SST-Cre mice, while inhibition of these neurons in the same mice had no effect. In addition, chemogenetic activation of these neurons did not cause apparent changes in models of anxiety-like behavior in either sex. Basal SST cell counts and intrinsic excitability of SST neurons were compared to attempt to understand sex differences in DREADD-induced changes in drinking, and while males had a greater number of BNST SST neurons, this effect went away when normalizing for total BNST volume. Together, these results suggest SST neurons in the BNST should be further explored as a potential neuronal subtype modulated by AUD, and for their therapeutic potential. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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