| Autor: |
Ye Ping, Ye Yuanyuan, Chen Xiaojing, Zou Hanbing, Zhou Yan, Zhao Xue, Chang Zhaohua, Han Baosan, Kong Xianming |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nanotechnology Reviews, Vol 9, Iss 1, Pp 61-69 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2191-9097 |
| DOI: |
10.1515/ntrev-2020-0006 |
| Popis: |
The ultrasmall nanoparticles easily lead to a more seriously response than larger nanoparticles because of their physicochemical features. It is essential to understand their cytotoxicity effects for their further application. Here, we used ultrasmall 9 nm Fe3O4 NPs to explore its cytotoxicity mechanism on breast cancer cells. We demonstrated 9 nm Fe3O4 NPswas effectively internalized into cells and located in nucleus, subsequently, it inhibited DNA synthesis through inducing S-phase arrest.Moreover, 9 nm Fe3O4 NPs induced ROS production and oxidative damage by disturbing the expression of antioxidant-related genes (HMOX-1, GCLC and GCLM), which resulted in the enhancement of cells apoptosis and inhibition of cell proliferation, suggesting its potential to be used as therapeutic drug. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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