Influence of serotonergic transmission and postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves)
| Autor: | P. L. Cedraz-Mercez, A. C. Almeida, R. H. Costa-e-Sousa, D. Badauê-Passos Jr., L. R. Castilhos, E. L. Olivares, A. Marinho Jr, M. A. Medeiros, L. C. Reis |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Brazilian Journal of Biology, Vol 65, Iss 4, Pp 589-595 |
| Druh dokumentu: | article |
| ISSN: | 1678-4375 1519-6984 |
| DOI: | 10.1590/S1519-69842005000400005 |
| Popis: | We investigated the role of 5-HT2C receptors and serotonergic transmission in the feeding behavior control of quails. Administration of serotonin releaser, fenfluramine (FEN) and 5-HT2C agonists, mCPP and MK212, 1.0 and 3.3 mg/Kg induced significant inhibition of food intake in previously fasted fowls (0.71 ± 0.18 g and 0.47 ± 0.2 g; 0.49 ± 0.22 g and 0.48 ± 0.29 g; 0.82 ± 0.13 g and 0.71 ± 0.16 g, respectively). Control groups ranged from 2.89 ± 0.21 g to 2.97 ± 0.22 g, 60 min after reintroduction of food, P < 0.0001). Similar results were obtained with normally fed quails. Both serotonin releaser and 5-HT2C agonists, in a 3.3 mg/Kg dose, induced hypophagy (FEN, 0.78 ± 0.08 g; mCPP, 0.89 ± 0.07 g; MK212, 1.25 ± 0.17 g vs. controls, 2.05 ± 0.12 g, 120 min after food was presented, P < 0.0001 to P < 0.01). Previous administration of 5-HT2C antagonist, LY53857 (5.0 mg/Kg) blocked the hypophagic response induced by 5-HT2C agonists 60 min after food was reintroduced. Current data show a modulatory role of serotonin release and postsynaptic 5-HT2C receptors in the feeding behavior of quails. |
| Databáze: | Directory of Open Access Journals |
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