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Sierra Cheng,1 Vanessa Arciero,1 Hanan Goldberg,2 Camilla Tajzler,3 Aileen Manganaro,4 Natascha Kozlowski,4 Leigha Rowbottom,1 Rachel McDonald,1 Ronald Chow,1 Gaurav Vasisht,3 Sharon Shaji,3 Emily Chu Lee Wong,3 Michele Petrovic,2 Liying Zhang,1 Cameron Phillips,1 Pawel Zalewski,4 Anil Kapoor,3 Neil E Fleshner,2 Edward Chow,1 Urban Emmenegger1 1Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada; 2Princess Margaret Cancer Centre, Toronto, Ontario, Canada; 3Juravinski Cancer Centre, Hamilton, Ontario, Canada; 4Durham Regional Cancer Centre, Oshawa, Ontario, CanadaCorrespondence: Urban EmmeneggerSunnybrook Odette Cancer Centre, 2075 Bayview Avenue, Toronto, Ontario M4N3M5, CanadaTel +1-416-480 4928Fax +1-416-480 6002Email urban.emmenegger@sunnybrook.caIntroduction: Radium-223 (Ra223) prolongs the survival and improves the quality of life of men with metastatic, castration-resistant prostate cancer (mCRPC) to bones. However, compared to other mCRPC therapies, using Ra223 comes with its unique challenges. Hence, we aimed to identify Ra223 utilization patterns under real-world conditions, as well as factors predicting treatment completion and outcome.Methods: In this retrospective chart analysis, 198 mCRPC patients were identified that had received Ra223 outside of clinical trials or access programs from January 2015 to October 2016 at four cancer centres in Ontario. The main outcomes studied were Ra223 completion rate, reasons for early treatment discontinuation, overall survival, and survival differences in patients completing Ra223 therapy versus patients receiving |
