| Autor: |
Jee H. Jung, Chong-O. Lee, Jongki Hong, Yoonmi Lee, Ping Zhang, Baoquan Bao |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 5, Iss 2, Pp 31-39 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md502031 |
| Popis: |
Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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