Research progress of NT5C2 in disease and treatment

Autor: SHU Ling, HUO Bennian, SONG Lin
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Jichu yixue yu linchuang, Vol 43, Iss 5, Pp 852-856 (2023)
Druh dokumentu: article
ISSN: 1001-6325
DOI: 10.16352/j.issn.1001-6325.2023.05.0852
Popis: Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells. High expression of cN-Ⅱ mRNA is associated with poor prognosis of patients with acute leukemia (AL). Acquired NT5C2 mutation will hinder the formation of DNA and thioguanine nucleotide (TGN) conjugate, resulting in 6-mercaptpurine(6-MP) resistance. In addition, NT5C2 is a risk factor associated with type Ⅱ diabetes, schizophrenia and other diseases.
Databáze: Directory of Open Access Journals