Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model
| Autor: | Aida Doostkam, Hossein Mirkhani, Kamyar Iravani, Saied Karbalay-Doust, Kazem Zarei |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Otorhinolaryngology, Vol 14, Iss 3, Pp 259-267 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1976-8710 2005-0720 |
| DOI: | 10.21053/ceo.2019.02068 |
| Popis: | Objectives Diabetic auditory neuropathy is a common complication of diabetes mellitus that has a major impact on patients’ quality of life. In this study, we assessed the efficacy of rutin in treating diabetic auditory neuropathy in an experimental rat model. Methods Forty Sprague-Dawley rats were randomly assigned to the following groups: group 1, control; group 2, diabetic rats; and groups 3–5, rats treated with rutin (at doses of 50, 100, and 150 mg/kg, respectively). We used auditory brain stem response, stereology of the spiral ganglion, and measurements of superoxide dismutase (SOD) and malondialdehyde (MDA) to evaluate the effects of treatment. Results Significant improvements in auditory neuropathy were observed in the rutin-treated groups in comparison with the diabetic group (P |
| Databáze: | Directory of Open Access Journals |
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