| Autor: |
H S Hendrickson |
| Jazyk: |
angličtina |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 17, Iss 4, Pp 393-398 (1976) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)34924-5 |
| Popis: |
The penetration of tetracaine into monolayers of phosphatidylcholine and trioctanoin at different surface pressures, and the penetration of dibucaine, tetracaine, butacaine, lidocaine, and procaine into monolayers of didecanoylphosphatidylcholine at Π = 10 mN/m was determined by the use of a modified Gibbs adsorption equation. These data were shown to fit a geometric model and compared favorably with data determined by a method based on the geometric model. The penetration of tetracaine into phosphatidylcholine monolayers was pressure dependent. At Π = 10 mN/m, the local anesthetics penetrate into a phosphatidylcholine monolayer in the order: dibucaine > tetracaine > butacaine > lidocaine > procaine. This correlates with their potencies in blocking nerve conduction and inhibiting phospholipase A2. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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