Sudden unexpected death after acute symptomatic seizures in a patient on mechanical ventilation

Autor: Raisa C. Martinez, Naoum P. Issa, Shasha Wu, Xi Liu, Sandra Rose, James X. Tao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Acta Epileptologica, Vol 2, Iss 1, Pp 1-5 (2020)
Druh dokumentu: article
ISSN: 2524-4434
DOI: 10.1186/s42494-020-00032-y
Popis: Abstract Background The mechanism of sudden unexpected death in epilepsy remains poorly understood. Seizure induced cardiac arrhythmia, central and obstructive apneas have been proposed as possible causes of death. Here we report a unique case of seizure related sudden unexpected death in a patient whose airway was fully protected by intubation and mechanic ventilation in the absence of fatal cardiac arrhythmia. Case presentation A 70-year-old woman was undergoing mechanical ventilation and video-electroencephalography (EEG) monitoring following two convulsive seizures with ictal hypoventilation and hypoxemia. Several hours after intubation, she suffered another generalized tonic clonic seizure lasted for 3 min and developed postictal generalized EEG suppression in the presence of stable vital signs with SpO2 > 90%. EEG suppression persisted throughout the postictal phase. There was a significant fluctuation of systolic blood pressure between 50 and 180 mmHg with several bouts of hypotension
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