Efficacy and safety of rituximab dosing for steroid-resistant idiopathic focal segmental glomerulosclerosis: a report of 12 cases

Autor: Ying-chao Peng, Zhi-qiang Zhang, Mei-qiu Wang, Xiang Fang, Chun-lin Gao, Tao Sun, Zheng-kun Xia
Jazyk: čínština
Rok vydání: 2024
Předmět:
Zdroj: Linchuang shenzangbing zazhi, Vol 24, Iss 2, Pp 108-115 (2024)
Druh dokumentu: article
ISSN: 1671-2390
DOI: 10.3969/j.issn.1671-2390.2024.02.004
Popis: ObjectiveTo evaluate the efficacy and safety of rituximab (RTX) for steroid-resistant idiopathic focal segmental glomerulosclerosis (FSGS) in children.MethodsFrom 2014 to 2020, the relevant clinical data were retrospectively reviewed for 12 children of steroid-resistant idiopathic FSGS .ResultsSteroid resistance was initial (n=10) and delayed (n=2). The age of initial RTX dosing was 8.00(5.15, 15.25) years. During a follow-up period of 6 months, complete remission (CR, n=3,) and partial remission (PR, n=1) were obtained. At the last follow-up, there were CR (n=1) and PR (n=2). Remission rate was higher in children on ≥3 doses than in those on
Databáze: Directory of Open Access Journals