| Autor: |
Thomas Robert, Guillaume Lano, Noémie Resseguier, Mickaël Bobot, Dammar Bouchouareb, Stéphane Burtey, Xavier de Lamballerie, Jean Dhorne, Bertrand Dussol, Ariane Duval, Julien Faraut, Toscane Fourié, Philippe Giaime, Mourad Hallah, Dominique Jaubert, Océane Jéhel, Tristan Legris, Stéphane Liotatis, Valérie Moal, Laetitia Ninove, Nathalie Pedinielli, Marion Pelletier, Manon Romeu-Giannoli, Mariela Saba, Marion Sallée, Laurent Samson, Adriana Saveanu, Violaine Scarfoglière, Pascale Sebahoun, Romain Vial, Clarissa Von Kotze, Philippe Brunet, Gaëtan Lebrun, Stanislas Bataille, Noémie Jourde-Chiche |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-022-15913-0 |
| Popis: |
Abstract Hemodialysis (HD) patients are at risk for severe COVID-19 and cannot comply with social distancing. SARS-COV2 seroprevalence in French patients and caregivers after the first wave of COVID-19 is unknown. SeroCOVIDial is a prospective study conducted between June and December 2020. SARS-COV2 seroprevalence was evaluated by a rapid serological test (BIOSYNEX) in HD patients and caregivers, and the presence or not of anti-SARS-COV2 neutralizing or non-neutralizing antibodies in patients was also determined by ELISA and seroneutralization. In June 2020, 451 HD patients and 238 caregivers were included. Overall SARS-COV2 seroprevalence was 8.4% (patients) and 6.7% (caregivers), and was 87.1% (patients) and 90.0% (caregivers) in participants with a previously documented SARS-COV2 infection. Overall seroprevalence reached 13.8% (patients) and 12.6% (caregivers) following the second epidemic wave. During the follow-up, 38 (8.4%) patients died (9 of COVID-19). Among the 44 (10.6%) patients who became infected, only two were seropositive at M0. The levels of anti-SARS-COV2 antibodies decreased over time in patients and caregivers. The BIOSYNEX test showed 82.9% sensitivity and 97.7% specificity. Prevalence of anti-SARS-COV2 antibodies was low in HD patients and caregivers after the first epidemic wave but rose after the second wave. A rapid serological test showed good performances and could be useful for future monitoring of anti-SARS-COV2 antibodies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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