An inflammatory marker for predicting prostate cancer in prostate biopsy: monocyte-to-lymphocyte ratio

Autor: Mehmet Kutlu Demirkol, Osman Barut, Enes Baki Bilecan, Tayfun Sahinkanat, Omer Faruk Boran, Mustafa Metin, Sefa Resim
Jazyk: English<br />Turkish
Rok vydání: 2021
Předmět:
Zdroj: Yeni Üroloji Dergisi, Vol 16, Iss 2, Pp 101-109 (2021)
Druh dokumentu: article
ISSN: 1305-2489
2687-1955
DOI: 10.33719/yud.2021;16-2-794684
Popis: Objective: To evaluate the predictive role of the inflammatory parameters, especially monocyte-to-lymphocyte (MLR) ratio, on the diagnosis of prostate cancer (PCa). Meterial and Methods: The data of patients undergoing prostate biopsy between July 2015 and July 2019 were retrospectively analyzed. The data including age, PSA, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), MLR and histopathologies were recorded. Patients were grouped as benign prostatic hyperplasia (BPH), PCa and prostatitis according to PBx histopathology and all variables were analyzed. Results: Pathology results of 338 patients are as follows: 124 (36.7%) BPH, 132 (39.1%) PCa and 82 (24.3%) prostatitis. Patients with PCa were older and had higher serum PSA, PLR, NLR and MLR values compared to non-PCa patients. In the comparison made by excluding metastatic patients, only serum PSA and MLR values remained statistically high. All three parameters had significant AUC to predict PCa in entire-cohort, but only the MLR had significant AUC to predict PCa in the cohort which metastatic patients were excluded. Multivariate logistic regression analysis revealed that only serum PSA and MLR values were significant independent predictors of PCa. Conclusion: All inflammatory markers were high in PCa patients, but, only MLR value remained high after metastatic PCa patients were excluded. MLR combination with PSA and age in the multivariate model is significant independent predictor of PCa.
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