Non-targeted Metabolomics Analysis of the Effects of Arabinogalactan on the Metabolites of Akkermansia muciniphila

Autor: Xirui FENG, Yanshi MA, Xiaoling WU, Xiangli KONG, Tianyang ZHANG, Dmitrii LOKHOV, Olga SERKOVA, Xiaoxi XU
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Shipin gongye ke-ji, Vol 43, Iss 7, Pp 21-34 (2022)
Druh dokumentu: article
ISSN: 1002-0306
DOI: 10.13386/j.issn1002-0306.2021100007
Popis: Among many plant polysaccharides, arabinogalactan had the best growth-promoting effect on Akkermansia muciniphila (Akk) model strain (DSM 22959). In order to further explore the influence of arabinogalactan on Akk metabolites, arabinogalactan was used as part of the carbon source to ferment Akk in vitro for the first time, and determined the supplementary amount of arabinogalactan to facilitate the Akk fermentation broth. In the subsequent analysis of the samples, high-resolution non-targeted metabolomics technology was used to detect and analyze the differential metabolites in the Akk fermentation broth samples. The results showed that there were 85 different metabolites (VIP>1, P
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