Characteristics of primary biliary cirrhosis in British Columbia's First Nations population

Autor: Laura Arbour, Rosemarie Rupps, Leigh Field, Paul Ross, Anders Erikson, Harvey Henderson, Warren Hill, Eric M Yoshida
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Canadian Journal of Gastroenterology, Vol 19, Iss 5, Pp 305-310 (2005)
Druh dokumentu: article
ISSN: 0835-7900
DOI: 10.1155/2005/203028
Popis: Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indication for referral for liver transplantation in British Columbia's First Nations population. Previously, an expanded review of all cases referred to the British Columbia Transplant Society for PBC was carried out comparing the demographics of those of First Nations descent with those not of First Nations descent. The review suggested that the rate of referral for transplantation was eight times higher for those of First Nations descent compared with those of other descent (P=0.0001), and a disproportionate number of the First Nations cases lived on Vancouver Island (48% of cases versus 18% expected, P
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