Apoptotic colopathy following bendamustine therapy

Autor: Vincent Czerwinski, Wei Cui, Marc Hoffmann
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Human Pathology Reports, Vol 34, Iss , Pp 300720- (2023)
Druh dokumentu: article
ISSN: 2772-736X
DOI: 10.1016/j.hpr.2023.300720
Popis: A 60-year-old woman with marginal zone lymphoma was treated with obinutuzumab and bendamustine after failing rituximab. She later developed intractable nausea and diarrhea which resulted in a dramatic weight loss and multiple hospitalizations. During her hospital stay the patient had a colonoscopy and biopsy which identified apoptotic colopathy- a pathologic condition characterized histologically by apoptosis. Her apoptotic colopathy was ultimately attributed to bendamustine, a previously unidentified trigger of apoptotic colopathy. The patient was eventually discharged on total parenteral nutrition (TPN) and has regained weight with adequate control of her diarrhea.
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