SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment

Autor: Marcella Prete, Elvira Favoino, Giacomo Catacchio, Vito Racanelli, Federico Perosa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 9, p 3377 (2020)
Druh dokumentu: article
ISSN: 21093377
1422-0067
1661-6596
DOI: 10.3390/ijms21093377
Popis: The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje