Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin

Autor:	Charlotte Esser
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	thymus immune system skin 2 3 7 8-tetrachlorodibenzo-p-dioxin (TCDD) aryl hydrocarbon receptor (AHR) therapeutic target Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 22, Iss 4, p 1844 (2021)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms22041844
Popis:	Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even “paradigmatic”, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor “aryl hydrocarbon receptor” (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4a3ec7a18e394f4d9e4e25ea206ee9be Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF