High expression of TMEM244 is associated with poor overall survival of patients with T-cell lymphoma

Autor: Cunte Chen, Shaohua Chen, Gengxin Luo, Liang Wang, Chengwu Zeng, Grzegorz K. Przybylski, Yangqiu Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biomarker Research, Vol 10, Iss 1, Pp 1-5 (2022)
Druh dokumentu: article
ISSN: 2050-7771
DOI: 10.1186/s40364-022-00395-z
Popis: Abstract T-cell lymphoma (TCL) is an aggressive and genetically heterogeneous malignancy with adverse clinical outcomes; thus, it is worth exploring biomarkers for risk stratification. Previous studies have demonstrated that transmembrane protein 244 gene (TMEM244) is ectopically expressed in Sézary syndrome (SS). In this study, the expression level of TMEM244 and its prognostic value for TCL patients was explored by analyzing RNA-seq data of two large datasets (GSE132550 and GSE113113) containing 129 TCL patients and 13 healthy individuals (HIs) from the Gene Expression Omnibus (GEO) database, the PRJCA002270 dataset containing 124 patients with T-cell acute lymphoblastic leukemia (T-ALL) from the BioProject database, and peripheral blood (PB) samples of 24 TCL and 29 T-ALL patients, as well as 11 normal CD3 + T-cells from our clinical center (JNU). The results suggested that TMEM244 was significantly up-regulated in TCL patients compared with normal CD3 + T-cells or T-ALL in the JNU, GSE132550 and GSE113113 datasets (P
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