| Autor: |
Lu-Yao Lai, Ying Jiang, Guang-Ping Su, Min Wu, Xiao-Fei Lu, Shao-Zhi Fu, Lu Yang, Jian Shu |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Materials Research Express, Vol 8, Iss 4, p 045001 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2053-1591 |
| DOI: |
10.1088/2053-1591/abf1a2 |
| Popis: |
CuFeSe _2 nanomaterial with high thermal conversion efficiency, well superparamagnetism, effective x-ray attenuation ability, multifunctional groups and excellent biocompatibility is beneficial to the construction of multimodal imaging probes which can combine various imaging modes to provide a synergistic advantage over a single imaging mode. This study aimed to develop a novel multimodal nanocontrast agent CuFeSe _2 @diethylenetriaminepentaacetic acid (DTPA)-Gd to obtain imaging information with high specificity, high sensitivity and high contrast. The morphology and physical characteristics of CuFeSe _2 @DTPA-Gd were detected by transmission electron microscope, scanning electron microscope, x-ray single crystal diffraction, vibrating sample magnetometer and fourier transform infrared spectrometer. The toxicity of CuFeSe _2 @DTPA-Gd in vivo was evaluated by hematoxylin-eosin staining. The imaging capability of CuFeSe _2 @DTPA-Gd in vitro and in vivo was evaluated by magnetic resonance imaging (MRI) and computed tomography (CT). This study successfully prepared nanoparticles CuFeSe _2 @DTPA-Gd, and experimental results in this study demonstrated CuFeSe _2 @DTPA-Gd is expected to be a useful CT and MRI T1-weighted imaging/T2-weighted imaging three-modal contrast agent in clinic. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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