Factors influencing height gain in children born small for gestational age treated with recombinant growth hormone: what extent is puberty involved?
| Autor: | Ramón Arroyo Ruiz, Aránzazu Ballester Pérez, Isabel Leiva-Gea, MªJosé Martínez-Aedo, Juan Pedro López-Siguero |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Endocrinology and Metabolism, Vol 13 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2042-0196 20420188 |
| DOI: | 10.1177/20420188221083534 |
| Popis: | Objective: The objective was to analyze the efficacy of recombinant human growth hormone (rhGH) treatment in children born small for gestational age (SGA) without catch-up growth treated before the onset of puberty, with follow-up until adult height. The influence of demographic and auxological factors on the final response evaluated as adult height and height gain was assessed. Patients and methods: A prospective longitudinal observational study performed in a tertiary hospital, involving SGA patients, who started treatment with rhGH between October 2003 and April 2015. Potential response predictors were evaluated by multiple regression analysis and receiver operating characteristic curves. Results: Of the initial 96 patients included, 61 patients (28 boys and 33 girls) reached adult height. Adult height gain in standard deviation (SDS) was 0.99 (0.8) and 1.49 (0.94), respectively ( p |
| Databáze: | Directory of Open Access Journals |
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