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Xi-Hu Yang,1,* Liang Ding,2,* Yong Fu,1 Sheng Chen,3 Lei Zhang,3 Xiao-Xin Zhang,2 Xiao-Feng Huang,3 Zhan-Yi Lu,1 Yan-Hong Ni,2 Qin-Gang Hu1 1Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210000, China; 2Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210000, China; 3Department of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210000, China *These authors contributed equally to this work Purpose: This was a retrospective analysis of the impact of the expression of p53 in the dysplastic surgical margins of early oral squamous cell carcinoma (OSCC) (pT1-2, N0). Patients and methods: Seventy-two patients with early oral squamous cell carcinoma (OSCC) were recruited. Margin characteristics were abstracted from the pathology report. Expression of p53 in dysplastic surgical margins was examined with the immunohistochemical method and was correlated with clinicopathological parameters and clinical outcomes. Results: Patients with moderate/severe dysplasia had poor local relapse-free survival (RFS) compared to those with mild dysplasia. Thirty-two (44.4%) had at least one p53-positive margin, and there was a significant association between the expression of p53 and tumor recurrence (P |
