Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.

Autor: Kai Chen, Yan Li, Yongdong Dai, Jiangchao Li, Yanru Qin, Yinghui Zhu, Tingting Zeng, Xiaojiao Ban, Li Fu, Xin-Yuan Guan
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 7, p e68838 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0068838
Popis: By using cDNA microarray analysis, we identified cornulin (CRNN) gene was frequently downregulated in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated the role of CRNN in ESCC development. The results showed that CRNN was frequently downregulated in primary ESCCs in both mRNA level (26/56, 46.4%) and protein level (137/249, 55%), which was significantly associated with lymph node metastases (P=0.027), advanced clinical stage (P=0.039), and overall survival rate (P
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