Effects of low frequency repetitive transcranial magnetic stimulation on motor recovery in subacute stroke patients with different motor evoked potential status: a randomized controlled trial

Autor: Wenjun Qian, Xiaoyu Liao, Xiaowen Ju, Yaxin Gao, Miao Wu, Chen Xie, Yaoying Zhang, Xianming Long, Surong Qian, Yan Gong
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Neurology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-2295
DOI: 10.3389/fneur.2024.1460925
Popis: ObjectivesTo explore the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on motor function and cortical excitability in stroke patients with different motor evoked potential (MEP) status.MethodsA total of 80 stroke patients were enrolled in this randomized controlled trial and divided into two groups according to MEP status (− or +) of lesioned hemisphere. Then, each group was randomly assigned to receive either active or sham LF-rTMS. In addition to conventional rehabilitation, all participants received 20 sessions of rTMS at 1 Hz frequency through the active or the sham coil over 4 weeks. Fugl-Meyer Assessment (FMA), National Institutes of Health Stroke Scale (NIHSS), Shoulder Abduction Finger Extension (SAFE) and Barthel Index (BI), bilateral resting motor threshold (rMT), amplitude of Motor evoked potential (MEP) and Central Motor Conduction Time (CMCT), and Interhemispheric asymmetry (IHA) were blindly assessed at baseline, 4 weeks and 8 weeks after treatment, respectively.ResultsAt 4 weeks after intervention, FMA and NIHSS changed scores in 1 Hz MEP(+) group were significantly higher than those in the other three groups (p
Databáze: Directory of Open Access Journals