Preoperative BRAF inhibition in patients with irresectable locally advanced stage III melanoma
| Autor: | Marloes Faut, Mathilde Jalving, Gilles F Diercks, Geke A Hospers, Barbara L van Leeuwen, Lukas B Been |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Melanoma Management, Vol 5, Iss 2 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2045-0893 2045-0885 |
| DOI: | 10.2217/mmt-2018-0002 |
| Popis: | Aim: Neoadjuvant treatment of locally advanced disease with BRAF inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with BRAF inhibitors. Methods: Patients with unresectable, BRAF-mutated, stage III melanoma, were treated with BRAF inhibitors between 2012 and 2015. Unresectability was determined based on clinical and/or radiological findings. At maximal response, resection was performed. The specimen was reviewed to determine the degree of response. Results: In five of six patients a radical resection was achieved. Postoperative complications were unremarkable. In five of six resected specimens, vital tumor tissue was found. Conclusion: Neoadjuvant BRAF inhibitor treatment of locally advanced melanoma is feasible and has the potential to facilitate an R0 resection. |
| Databáze: | Directory of Open Access Journals |
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