| Autor: |
Yajuan Mu, Yue Wang, Yanfei Huang, Dong Li, Youyou Han, Min Chang, Jiaqi Fu, Yongchao Xie, Jie Ren, Hao Wang, Yi Zhang, Zhao-Qing Luo, Yue Feng |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-15645-7 |
| Popis: |
The Legionella effector MavC catalyses the ubiquitination of the E2 enzyme UBE2N in the host cell through a transglutamination reaction, which can be inhibited by the Legionella effector Lpg2149. Here, the authors provide mechanistic insights into these processes by determining the crystal structures of the MavC/UBE2N/Ub ternary complex, the MavC/UBE2N-Ub product complex and the MavC/Lpg2149 complex. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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