Optimising size and depth of punch grafts in autologous transplantation of vitiligo and piebaldism: a randomised controlled trial

Autor: Lisa Komen, Charlotte Vrijman, Cecilia A. C. Prinsen, J. P. Wietze van der Veen, Rosalie M. Luiten, Albert Wolkerstorfer
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Dermatological Treatment, Vol 28, Iss 1, Pp 86-91 (2017)
Druh dokumentu: article
ISSN: 0954-6634
1471-1753
09546634
DOI: 10.1080/09546634.2016.1179251
Popis: Background: To date, autologous punch grafting appears to be the easiest and least expensive surgical technique for stable vitiligo and piebaldism. Punch grafting is available worldwide, with no need for specialised instruments. However, no reliable data on efficacy and safety of different punch depths and punch sizes are available. Objective/methods: To compare the efficacy and safety of different punch depths and punch sizes in autologous punch grafting, a randomised controlled trial was performed in 33 patients with vitiligo or piebaldism. In each patient, four depigmented regions were allocated to: 1.5 mm deep grafts, 1.5 mm superficial grafts, 1.0 mm deep grafts, and 1.0 mm superficial grafts. Primary outcome was the total pigmented surface area. Secondary outcomes were Patients’ Global Assessment (PGA) and side effects. Results: Six months after grafting, 1.5 mm grafts showed a significantly larger pigmented surface area compared to 1.0-mm grafts (p
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