| Autor: |
Sarng S. Pyurvee, Andrei A. Lebedev, Eugeny R. Bychkov, Petr D. Shabanov |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Research Results in Pharmacology, Vol 10, Iss 2, Pp 97-105 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2658-381X |
| DOI: |
10.18413/rrpharmacology.10.448 |
| Popis: |
Introduction: The aim of our study was to investigate the effects of ghrelin receptor antagonist [D-Lys-3]-GHRP-6 on impulsivity and compulsivity in a model of gambling addiction in adult rats after maternal deprivation MD in early ontogenesis. Materials and Methods: The cubs were deprived of their mother daily for 3 h from days 2 to 12 postnatal. Adult Wistar rats were trained in a three-arm maze for 21 days. Two seeds were fed in arm 1 with reinforcement mode FR1. In arm 2, three seeds were presented with reinforcement mode FR2; in arms 3, 4 seeds were presented with reinforcement mode FR3 (i.e., only every 3rdrun to the feeder was reinforced with food). The animals were also examined to quantify their status of compulsive behavior in a marble test. The rat was placed in the cage with sawdust and glass beads for 30 min, after which, the number of balls covered with sawdust by more than 2/3 was counted. Results: In the MD group, the number of entrances to arm 3 increased 1.5-fold, indicating the selection of a larger reinforcement value at its low probability. The number of entrances to arm 1 (reward with high probability (100%) but with the lowest food reinforcement) decreased compared to the control group. The intranasal administration of the selective GHSR1A receptor antagonist [D-Lys (3)]-GHRP-6 (1 mg/mL) to animals MD led to significant (p |
| Databáze: |
Directory of Open Access Journals |
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