Expression of IL-17 and COX2 Gene in Peripheral Blood Leukocytes of Vitiligo Patients
| Autor: | Behnaz Esmaeili, Seyed Abdol Rahim Rezaee, Pouran Layegh, Jalil Tavakkol Afshari, Phil Dye, Ehsan Ghayoor Karimiani, Fatemeh Kalalinia, Houshang Rafatpanah |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Iranian Journal of Allergy, Asthma and Immunology, Vol 10, Iss 2 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1735-1502 1735-5249 |
| Popis: | Vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. Interleukin 17 (IL-17A) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (COX2). The aim of this study was to investigate the gene expression of IL-17 and COX2 in peripheral blood leukocytes of vitiligo's patients. Peripheral blood leukocytes from 15 patients with vitiligo and 15 healthy controls were separated using a gradient density centrifugation method. After total RNA isolation and cDNA synthesis, IL-17 and COX2 gene expression were quantified by real-time polymerase chain reaction (PCR). There were no significant differences in IL-17 and COX2 gene expression in lymphocytes of patients with vitiligo compared with control group (p |
| Databáze: | Directory of Open Access Journals |
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