Effect of Caryocar coriaceum Wittm. fixed oil on body weight and metabolic parameters of mice fed a high-fat diet
| Autor: | Aline Almeida da Silva, Otília Monica Alves Borges, Nylane Maria Nunes de Alencar, Renata Prado Vasconcelos, Ariclécio Cunha de Oliveira, Socorro Vanesca Frota Gaban |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Food Chemistry Advances, Vol 5, Iss , Pp 100855- (2024) |
| Druh dokumentu: | article |
| ISSN: | 2772-753X 14298449 |
| DOI: | 10.1016/j.focha.2024.100855 |
| Popis: | This study examined the effects of C. coriaceum-fixed oil in mice fed a high-fat diet (HFD). The animals were divided into three groups: those receiving a standard diet (SD), those on an HFD, and those on a high-fat diet supplemented with pequi-fixed oil (HFDPO). The animals were maintained on their respective diets for a duration of 27 weeks, during which the pequi fixed oil (100 mg/kg/day) was administered orally via gavage once daily for the final 9 weeks of the study. A glucose tolerance test was performed 1 day before animal sacrifice, and adipose tissue samples were collected. Although all groups initially had similar food intakes, the HFD and HFDPO groups showed reduced food intake compared with the standard diet group. Both groups also had increased body weights and higher fat weights than the SD group. Additionally, the HFD and HFDPO groups had higher glucose levels and significantly higher area under the curves (AUCs) than the SD group. There were no significant differences in the glucose tolerance test (GTT) and AUC between the HFD and HFDPO groups. In this study, pequi-fixed oil was ineffective in treating obesity induced by a high-fat diet. |
| Databáze: | Directory of Open Access Journals |
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