Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of bla TEM-1B

Autor: Alasdair T. M. Hubbard, Jenifer Mason, Paul Roberts, Christopher M. Parry, Caroline Corless, Jon van Aartsen, Alex Howard, Issra Bulgasim, Alice J. Fraser, Emily R. Adams, Adam P. Roberts, Thomas Edwards
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18668-2
Popis: An E. coli and K. pneumoniae phenotype resistant to piperacillin/tazobactam has recently emerged. Here, the authors show that hyperproduction of the β-lactamase driving this resistance occurs due to excision and reinsertion of a translocatable unit containing bla TEM-1B, creating a tandem array.
Databáze: Directory of Open Access Journals