| Autor: |
Muhammad Zain Chauhan, Jennifer Arcuri, Kevin K. Park, Maroof Khan Zafar, Rabeet Fatmi, Abigail S. Hackam, Yuqin Yin, Larry Benowitz, Jeffrey L. Goldberg, Mohammad Samarah, Sanjoy K. Bhattacharya |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 23, Iss 2, Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2020.100836 |
| Popis: |
Summary: Growth cones (GCs) are structures associated with growing neurons. GC membrane expansion, which necessitates protein-lipid interactions, is critical to axonal elongation in development and in adult neuritogenesis. We present a multi-omic analysis that integrates proteomics and lipidomics data for the identification of GC pathways, cell phenotypes, and lipid-protein interactions, with an analytic platform to facilitate the visualization of these data. We combine lipidomic data from GC and adult axonal regeneration following optic nerve crush. Our results reveal significant molecular variability in GCs across developmental ages that aligns with the upregulation and downregulation of lipid metabolic processes and correlates with distinct changes in the lipid composition of GC plasmalemma. We find that these processes also define the transition into a growth-permissive state in the adult central nervous system. The insight derived from these analyses will aid in promoting adult regeneration and functional innervation in devastating neurodegenerative diseases. : Biological Sciences; Systems Biology; Omics; Proteomics; Lipidomics Subject Areas: Biological Sciences, Systems Biology, Omics, Proteomics, Lipidomics |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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