| Autor: |
Tang Yuelian, Wang Xinyan, Li Gang, Liu Dongbing, Liu Jiaxin |
| Jazyk: |
čínština |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Xin yixue, Vol 54, Iss 10, Pp 723-727 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0253-9802 |
| DOI: |
10.3969/j.issn.0253-9802.2023.10.007 |
| Popis: |
Objective To explore the risk factors of re-positive after eradication therapy in patients with peptic ulcer（PU） complicated with Helicobacter pylori（Hp）infection， and to establish and verify a risk warning. Methods A total of 120 patients with PU complicated with Hp infection who underwent eradication therapy were selected. According to whether the patients were re-positive， they were divided into the re-positive group（n = 17）and non-re-positive group（n = 103）. Logistic regression analysis was performed on potential related factors， and a risk model was constructed and verified. Results The re-positive rate of 120 PU patients complicated with Hp infection after eradication therapy was 14.17%. Logistic regression analysis showed that smoking history（OR = 3.255）， alcohol abuse history（OR = 5.170）， NSAID application history（OR = 3.136 ， gastroscopy after eradication therapy（OR = 6.545）， SAS score（OR = 1.119）， SDS score（OR = 1.210）， maximum diameter of ulcer（OR = 4.450）and number of ulcer（OR =1.307）were the independent risk factors for re-positive after eradication therapy in patients with PU complicated with Hp infection（all P < 0.05）. Regular eating habit （OR = 0.034 ） was the independent protective factor（P < 0.05）. The area under the ROC curve （AUC） was 0.949（P < 0.001，95%CI 0.899-0.998）， the sensitivity was 88.20%， the specificity was 92.20%， and the maximum Youden index was 0.804. The prediction accuracy in clinical application was 81.67%. Conclusions The re-positive of PU patients complicated with Hp infection after eradication therapy is affected by multiple factors. The risk warning model established based on these risk factors yields high predictive efficacy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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