The nucleoid as a scaffold for the assembly of bacterial signaling complexes.
| Autor: | Audrey Moine, Leon Espinosa, Eugenie Martineau, Mutum Yaikhomba, P J Jazleena, Deborah Byrne, Emanuele G Biondi, Eugenio Notomista, Matteo Brilli, Virginie Molle, Pananghat Gayathri, Tâm Mignot, Emilia M F Mauriello |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | PLoS Genetics, Vol 13, Iss 11, p e1007103 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1553-7390 1553-7404 |
| DOI: | 10.1371/journal.pgen.1007103 |
| Popis: | The FrzCD chemoreceptor from the gliding bacterium Myxococcus xanthus forms cytoplasmic clusters that occupy a large central region of the cell body also occupied by the nucleoid. In this work, we show that FrzCD directly binds to the nucleoid with its N-terminal positively charged tail and recruits active signaling complexes at this location. The FrzCD binding to the nucleoid occur in a DNA-sequence independent manner and leads to the formation of multiple distributed clusters that explore constrained areas. This organization might be required for cooperative interactions between clustered receptors as observed in membrane-bound chemosensory arrays. |
| Databáze: | Directory of Open Access Journals |
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